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apalutamide will minimize the extent or influence of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication that are CYP3A4 substrates may result in lower exposure to those drugs.Because of these changes in practice and, also,